diff --git a/src/button/ReactionToggleButton.tsx b/src/button/ReactionToggleButton.tsx
index 583a1cd2..9dbcc617 100644
--- a/src/button/ReactionToggleButton.tsx
+++ b/src/button/ReactionToggleButton.tsx
@@ -224,26 +224,34 @@ export function ReactionToggleButton({
   const { raisedHands, lowerHand, reactions } = useReactions();
   const [busy, setBusy] = useState(false);
   const userId = client.getUserId()!;
-  const isHandRaised = !!raisedHands[userId];
   const memberships = useMatrixRTCSessionMemberships(rtcSession);
   const [showReactionsMenu, setShowReactionsMenu] = useState(false);
   const [errorText, setErrorText] = useState<string>();
 
+  const myMembershipEventId = useMemo(
+    () =>
+      memberships.find(
+        (m) =>
+          m.sender === client.getUserId() &&
+          m.deviceId === client.getDeviceId(),
+      ),
+    [memberships],
+  )?.eventId;
+
   useEffect(() => {
     // Clear whenever the reactions menu state changes.
     setErrorText(undefined);
   }, [showReactionsMenu]);
 
-  const canReact = !reactions[userId];
+  const canReact = !reactions[myMembershipEventId ?? ""];
+  const isHandRaised = !!raisedHands[myMembershipEventId ?? ""];
 
   const sendRelation = useCallback(
     async (reaction: ReactionOption) => {
       try {
-        const myMembership = memberships.find((m) => m.sender === userId);
-        if (!myMembership?.eventId) {
-          throw new Error("Cannot find own membership event");
+        if (!myMembershipEventId) {
+          throw Error("Could not find own membership event");
         }
-        const parentEventId = myMembership.eventId;
         setBusy(true);
         await client.sendEvent(
           rtcSession.room.roomId,
@@ -251,7 +259,7 @@ export function ReactionToggleButton({
           {
             "m.relates_to": {
               rel_type: RelationType.Reference,
-              event_id: parentEventId,
+              event_id: myMembershipEventId,
             },
             emoji: reaction.emoji,
             name: reaction.name,
@@ -266,7 +274,7 @@ export function ReactionToggleButton({
         setBusy(false);
       }
     },
-    [memberships, client, userId, rtcSession],
+    [myMembershipEventId, client, rtcSession],
   );
 
   const toggleRaisedHand = useCallback(() => {
@@ -281,11 +289,9 @@ export function ReactionToggleButton({
         }
       } else {
         try {
-          const myMembership = memberships.find((m) => m.sender === userId);
-          if (!myMembership?.eventId) {
-            throw new Error("Cannot find own membership event");
+          if (!myMembershipEventId) {
+            throw Error("Could not find own membership event");
           }
-          const parentEventId = myMembership.eventId;
           setBusy(true);
           const reaction = await client.sendEvent(
             rtcSession.room.roomId,
@@ -293,7 +299,7 @@ export function ReactionToggleButton({
             {
               "m.relates_to": {
                 rel_type: RelationType.Annotation,
-                event_id: parentEventId,
+                event_id: myMembershipEventId,
                 key: "🖐️",
               },
             },
@@ -314,10 +320,9 @@ export function ReactionToggleButton({
   }, [
     client,
     isHandRaised,
-    memberships,
+    myMembershipEventId,
     lowerHand,
     rtcSession.room.roomId,
-    userId,
   ]);
 
   return (
diff --git a/src/useReactions.test.tsx b/src/useReactions.test.tsx
index 6140793f..fd7c38c1 100644
--- a/src/useReactions.test.tsx
+++ b/src/useReactions.test.tsx
@@ -21,6 +21,7 @@ import {
 
 const memberUserIdAlice = "@alice:example.org";
 const memberEventAlice = "$membership-alice:example.org";
+const memberEventAlice2 = "$membership-alice2:example.org";
 const memberUserIdBob = "@bob:example.org";
 const memberEventBob = "$membership-bob:example.org";
 
@@ -28,6 +29,8 @@ const membership: Record<string, string> = {
   [memberEventAlice]: memberUserIdAlice,
   [memberEventBob]: memberUserIdBob,
   "$membership-charlie:example.org": "@charlie:example.org",
+  // Second device
+  [memberEventAlice2]: memberEventAlice,
 };
 
 /**
@@ -42,9 +45,9 @@ const TestComponent: FC = () => {
   return (
     <div>
       <ul>
-        {Object.entries(raisedHands).map(([userId, date]) => (
-          <li key={userId}>
-            <span>{userId}</span>
+        {Object.entries(raisedHands).map(([membershipEventId, date]) => (
+          <li key={membershipEventId}>
+            <span>{membershipEventId}</span>
             <time>{date.getTime()}</time>
           </li>
         ))}
@@ -170,4 +173,17 @@ describe("useReactions", () => {
     await act(() => room.testSendHandRaise(memberEventAlice, memberUserIdBob));
     expect(queryByRole("list")?.children).to.have.lengthOf(0);
   });
+  test("handles multiple membership event reactions for the same sender", () => {
+    const room = new MockRoom(memberUserIdAlice, [
+      createHandRaisedReaction(memberEventAlice, membership),
+      createHandRaisedReaction(memberEventAlice2, membership),
+    ]);
+    const rtcSession = new MockRTCSession(room, membership);
+    const { queryByRole } = render(
+      <TestReactionsWrapper rtcSession={rtcSession}>
+        <TestComponent />
+      </TestReactionsWrapper>,
+    );
+    expect(queryByRole("list")?.children).to.have.lengthOf(2);
+  });
 });
diff --git a/src/useReactions.tsx b/src/useReactions.tsx
index 9111d5a9..201ba9ef 100644
--- a/src/useReactions.tsx
+++ b/src/useReactions.tsx
@@ -48,9 +48,9 @@ const ReactionsContext = createContext<ReactionsContextType | undefined>(
 
 interface RaisedHandInfo {
   /**
-   * Call membership event that was reacted to.
+   * The sender who sent the raised hand.
    */
-  membershipEventId: string;
+  sender: string;
   /**
    * Event ID of the reaction itself.
    */
@@ -71,6 +71,8 @@ export const useReactions = (): ReactionsContextType => {
   return context;
 };
 
+type MembershipEventId = string;
+
 /**
  * Provider that handles raised hand reactions for a given `rtcSession`.
  */
@@ -82,7 +84,7 @@ export const ReactionsProvider = ({
   rtcSession: MatrixRTCSession;
 }): JSX.Element => {
   const [raisedHands, setRaisedHands] = useState<
-    Record<string, RaisedHandInfo>
+    Record<MembershipEventId, RaisedHandInfo>
   >({});
   const memberships = useMatrixRTCSessionMemberships(rtcSession);
   const clientState = useClientState();
@@ -91,29 +93,36 @@ export const ReactionsProvider = ({
   const room = rtcSession.room;
   const myUserId = room.client.getUserId();
 
-  const [reactions, setReactions] = useState<Record<string, ReactionOption>>(
-    {},
-  );
+  const [reactions, setReactions] = useState<
+    Record<MembershipEventId, ReactionOption>
+  >({});
 
   // Reduce the data down for the consumers.
   const resultRaisedHands = useMemo(
     () =>
       Object.fromEntries(
-        Object.entries(raisedHands).map(([uid, data]) => [uid, data.time]),
+        Object.entries(raisedHands).map(([membershipEventId, data]) => [
+          membershipEventId,
+          data.time,
+        ]),
       ),
     [raisedHands],
   );
 
-  const addRaisedHand = useCallback((userId: string, info: RaisedHandInfo) => {
-    setRaisedHands((prevRaisedHands) => ({
-      ...prevRaisedHands,
-      [userId]: info,
-    }));
-  }, []);
+  const addRaisedHand = useCallback(
+    (membershipEventId: string, info: RaisedHandInfo) => {
+      setRaisedHands((prevRaisedHands) => ({
+        ...prevRaisedHands,
+        [membershipEventId]: info,
+      }));
+    },
+    [],
+  );
 
-  const removeRaisedHand = useCallback((userId: string) => {
+  const removeRaisedHand = useCallback((membershipEventId: string) => {
     setRaisedHands(
-      ({ [userId]: _removed, ...remainingRaisedHands }) => remainingRaisedHands,
+      ({ [membershipEventId]: _removed, ...remainingRaisedHands }) =>
+        remainingRaisedHands,
     );
   }, []);
 
@@ -138,11 +147,10 @@ export const ReactionsProvider = ({
       );
     };
 
-    // Remove any raised hands for users no longer joined to the call.
-    for (const userId of Object.keys(raisedHands).filter(
-      (rhId) => !memberships.find((u) => u.sender == rhId),
+    for (const previousMemberEventId of Object.keys(raisedHands).filter(
+      (eventId) => !memberships.some((m) => m.eventId === eventId),
     )) {
-      removeRaisedHand(userId);
+      removeRaisedHand(previousMemberEventId);
     }
 
     // For each member in the call, check to see if a reaction has
@@ -151,22 +159,14 @@ export const ReactionsProvider = ({
       if (!m.sender || !m.eventId) {
         continue;
       }
-      if (
-        raisedHands[m.sender] &&
-        raisedHands[m.sender].membershipEventId !== m.eventId
-      ) {
-        // Membership event for sender has changed since the hand
-        // was raised, reset.
-        removeRaisedHand(m.sender);
-      }
       const reaction = getLastReactionEvent(m.eventId, m.sender);
       if (reaction) {
         const eventId = reaction?.getId();
         if (!eventId) {
           continue;
         }
-        addRaisedHand(m.sender, {
-          membershipEventId: m.eventId,
+        addRaisedHand(m.eventId, {
+          sender: m.sender,
           reactionEventId: eventId,
           time: new Date(reaction.localTimestamp),
         });
@@ -241,19 +241,21 @@ export const ReactionsProvider = ({
         };
 
         setReactions((reactions) => {
-          if (reactions[sender]) {
+          if (reactions[membershipEventId]) {
             // We've still got a reaction from this user, ignore it to prevent spamming
             return reactions;
           }
           const timeout = setTimeout(() => {
             // Clear the reaction after some time.
-            setReactions(({ [sender]: _unused, ...remaining }) => remaining);
+            setReactions(
+              ({ [membershipEventId]: _unused, ...remaining }) => remaining,
+            );
             reactionTimeouts.delete(timeout);
           }, REACTION_ACTIVE_TIME_MS);
           reactionTimeouts.add(timeout);
           return {
             ...reactions,
-            [sender]: reaction,
+            [membershipEventId]: reaction,
           };
         });
       } else if (event.getType() === EventType.Reaction) {
@@ -274,9 +276,9 @@ export const ReactionsProvider = ({
         }
 
         if (content?.["m.relates_to"].key === "🖐️") {
-          addRaisedHand(sender, {
+          addRaisedHand(membershipEventId, {
             reactionEventId,
-            membershipEventId,
+            sender,
             time: new Date(event.localTimestamp),
           });
         }
@@ -316,11 +318,22 @@ export const ReactionsProvider = ({
     latestRaisedHands,
   ]);
 
+  const myMembershipEventId = useMemo(
+    () =>
+      memberships.find(
+        (m) =>
+          clientState?.state === "valid" &&
+          m.sender === clientState.authenticated?.client.getUserId() &&
+          m.deviceId === clientState.authenticated?.client.getDeviceId(),
+      ),
+    [memberships],
+  )?.eventId;
+
   const lowerHand = useCallback(async () => {
-    if (!myUserId || !raisedHands[myUserId]) {
+    if (!myMembershipEventId || !raisedHands[myMembershipEventId]) {
       return;
     }
-    const myReactionId = raisedHands[myUserId].reactionEventId;
+    const myReactionId = raisedHands[myMembershipEventId].reactionEventId;
     if (!myReactionId) {
       logger.warn(`Hand raised but no reaction event to redact!`);
       return;
@@ -331,7 +344,7 @@ export const ReactionsProvider = ({
     } catch (ex) {
       logger.error("Failed to redact reaction event", myReactionId, ex);
     }
-  }, [myUserId, raisedHands, rtcSession, room]);
+  }, [myMembershipEventId, raisedHands, rtcSession, room]);
 
   return (
     <ReactionsContext.Provider
diff --git a/src/utils/testReactions.tsx b/src/utils/testReactions.tsx
index 99557e8a..6ccf695f 100644
--- a/src/utils/testReactions.tsx
+++ b/src/utils/testReactions.tsx
@@ -45,6 +45,7 @@ export class MockRTCSession extends EventEmitter {
   public memberships: {
     sender: string;
     eventId: string;
+    deviceId: string;
     createdTs: () => Date;
   }[];
 
@@ -56,6 +57,7 @@ export class MockRTCSession extends EventEmitter {
     this.memberships = Object.entries(membership).map(([eventId, sender]) => ({
       sender,
       eventId,
+      deviceId: randomUUID(),
       createdTs: (): Date => new Date(),
     }));
   }
@@ -69,6 +71,7 @@ export class MockRTCSession extends EventEmitter {
     this.memberships.push({
       sender,
       eventId: `!fake-${randomUUID()}:event`,
+      deviceId: randomUUID(),
       createdTs: (): Date => new Date(),
     });
     this.emit(MatrixRTCSessionEvent.MembershipsChanged);
@@ -118,6 +121,7 @@ export class MockRoom extends EventEmitter {
 
   public constructor(
     private readonly ownUserId: string,
+    private readonly ownDeviceId: string,
     private readonly existingRelations: MatrixEvent[] = [],
   ) {
     super();
@@ -126,6 +130,7 @@ export class MockRoom extends EventEmitter {
   public get client(): MatrixClient {
     return {
       getUserId: (): string => this.ownUserId,
+      getDeviceId: (): string => this.ownDeviceId,
       sendEvent: async (
         ...props: Parameters<MatrixClient["sendEvent"]>
       ): ReturnType<MatrixClient["sendEvent"]> => {